Testing Efficiency in NHL Betting Markets

The efficiency of markets is a prominent topic in the field of finance. Market efficiency has been thoroughly examined across many subsectors of finance; however thus far, existing research has sparsely covered the increasingly prominent sports betting market. This market is currently valued at roughly $10B per year (Grandview). In this article, we evaluate the efficiency of sports betting markets, using NHL betting lines and results from 2015-2020 to create a multivariate probit model which tests the market’s efficiency. Using a multivariate probit model to identify NHL money line bets with a relatively high probability of success compared to their implied probability, we generate significant profit and beat betting markets, generating an 8.5% ROI when tested against the 20-21 NHL season

HES5 silencing is an early and recurrent change in prostate tumourigenesis.

Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent founder mutations, consistent with non-genetic disease initiating events. Using methylation profiling in a series of multi-focal prostate tumours, we identify promoter methylation of the transcription factor HES5 as an early event in prostate tumourigenesis. We confirm that this epigenetic alteration occurs in 86-97% of cases in two independent prostate cancer cohorts (n=49 and n=39 tumour-normal pairs). Treatment of prostate cancer cells with the demethylating agent 5-aza-2'-deoxycytidine increased HES5 expression and downregulated its transcriptional target HES6, consistent with functional silencing of the HES5 gene in prostate cancer. Finally, we identify and test a transcriptional module involving the AR, ERG, HES1 and HES6 and propose a model for the impact of HES5 silencing on tumourigenesis as a starting point for future functional studies.The authors are grateful to study volunteers for their participation and staff at the Welcome Trust Clinical Research Facility, Addenbrooke’s Clinical Research Centre, Cambridge. They also thank the NIHR Cambridge Biomedical Research Centre, the DOH HTA (ProtecT grant), and the NCRI/MRC (ProMPT grant) for help with the bio-repository, The University of Cambridge, Hutchison Whampoa Limited and Cancer Research UK for funding. They are grateful to the CRUK Cambridge Institute Genomics and Bioinformatics Core Facilities. Cross-validation of HES5 methylation includes the use of data generated by the TCGA Research Network.This is the final version of the article. It was originally published in the Endocrine-Related Cancer, April 1, 2015 22 131-144 doi: 10.1530/ERC-14-0454

“A Devil's Engine”: Photography and Spirits in the Western Solomon Islands

This article looks at photographic practices in Roviana Lagoon in the western Solomon Islands of the South Pacific. It argues that the efficacy or affective power of photographs in this context must be understood in terms of what is locally called maqomaqo (soul or shadow). Photographs contain a material trace of the essence of what they portray, which enables them to “touch” their viewers. This case study allows us to think about the innate metaphysic of photography, and about the way in which “photography” only ever exists as a series of local photographies, which emerge from the interplay between this innate metaphysic of the photographic technology and local ontologies